Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/30099
Title: Stretch-activated channels in stretch-induced muscle damage : role in muscular dystrophy
Authors: Yeung, EW 
Allen, DG
Keywords: Contraction-induced injury
Dystrophin
Eccentric contractions
Muscular dystrophy
Single fibres
Stretch
Issue Date: 2004
Source: Clinical and experimental pharmacology and physiology, 2004, v. 31, no. 8, p. 551-556 How to cite?
Journal: Clinical and Experimental Pharmacology and Physiology 
Abstract: 1. Stretch-induced muscle injury results in the damage that causes reduced force and increased membrane permeability. This muscle damage is caused, in part, by ionic entry through stretch-activated channels and blocking these channels with Gd3+ or streptomycin reduces the force deficit associated with damage. 2. Dystrophin-deficient muscles are more susceptible to stretch-induced muscle injury and the recovery from injury can be incomplete. We have found that Na+ entry associated with stretch-induced injury is enhanced in dystrophin-deficient muscles and that blockers of stretch-activated channels are capable of preventing ionic entry and reducing muscle damage. 3. A model is presented that proposes links between stretch-induced injury, opening of stretch-activated channels, increased levels of intracellular ions and various forms of muscle damage. Although changes in Na+ accompany stretch-induced muscle injury, we believe that changes in Ca2+ probably have a more central role in the damage process.
URI: http://hdl.handle.net/10397/30099
ISSN: 0305-1870
DOI: 10.1111/j.1440-1681.2004.04027.x
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