Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29767
Title: Ultrasound evaluation of site-specific effect of simulated microgravity on articular cartilage
Authors: Wang, Q
Zheng, YP 
Wang, XY
Huang, YP
Liu, MQ
Wang, SZ
Zhang, ZK
Guo, X 
Keywords: Articular cartilage
Simulated microgravity
Site-dependence
Surface roughness
Ultrasound biomicroscopy
Issue Date: 2010
Publisher: Elsevier
Source: Ultrasound in medicine and biology, 2010, v. 36, no. 7, p. 1089-1097 How to cite?
Journal: Ultrasound in medicine and biology 
Abstract: Space flight induces acute changes in normal physiology in response to the microgravity environment. Articular cartilage is subjected to high loads under a ground reaction force on Earth. The objectives of this study were to investigate the site dependence of morphological and ultrasonic parameters of articular cartilage and to examine the site-specific responses of articular cartilage to simulated microgravity using ultrasound biomicroscopy (UBM). Six rats underwent tail suspension (simulated microgravity) for four weeks and six other rats were kept under normal Earth gravity as controls. Cartilage thickness, ultrasound roughness index (URI), integrated reflection coefficient (IRC) and integrated backscatter coefficient (IBC) of cartilage tissues, as well as histological degeneration were measured at the femoral head (FH), medial femoral condyle (MFC), lateral femoral condyle (LFC), patello-femoral groove (PFG) and patella (PAT). The results showed site dependence not significant in all UBM parameters except cartilage thickness (p < 0.01) in the control specimens. Only minor changes in articular cartilage were induced by 4-week tail suspension, although there were significant decreases in cartilage thickness at the MFC and PAT (p < 0.05) and a significant increase in URI at the PAT (p < 0.01). This study suggested that the 4-week simulated microgravity had only mild effects on femoral articular cartilage in the rat model. This information is useful for human spaceflight and clinical medicine in improving understanding of the effect of microgravity on articular cartilage. However, the effects of longer duration microgravity experience on articular cartilage need further investigation. (E-mail: rsguoxia@inet.polyu.edu.hk).
URI: http://hdl.handle.net/10397/29767
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2010.04.018
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

11
Last Week
0
Last month
0
Citations as of Sep 19, 2017

WEB OF SCIENCETM
Citations

8
Last Week
0
Last month
1
Citations as of Sep 21, 2017

Page view(s)

57
Last Week
2
Last month
Checked on Sep 25, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.