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Title: A Continuum model for pressure-flow relationship in human pulmonary circulation
Authors: Huang, W
Zhou, Q
Gao, J
Yen, RT
Keywords: Capillary sheet
Continuum model
Pressure-flow relationship
Pulmonary circulation
Steady flow
Issue Date: 2011
Source: Mcb molecular and cellular biomechanics, 2011, v. 8, no. 2, p. 105-122 How to cite?
Journal: MCB Molecular and Cellular Biomechanics 
Abstract: A continuum model was introduced to analyze the pressure-flow relationship for steady flow in human pulmonary circulation. The continuum approach was based on the principles of continuum mechanics in conjunction with detailed measurement of vascular geometry, vascular elasticity and blood rheology. The pulmonary arteries and veins were considered as elastic tubes and the "fifth-power law" was used to describe the pressure-flow relationship. For pulmonary capillaries, the "sheet-flow" theory was employed and the pressure-flow relationship was represented by the "fourth-power law". In this paper, the pressure-flow relationship for the whole pulmonary circulation and the longitudinal pressure distribution along the streamlines were studied. Our computed data showed general agreement with the experimental data for the normal subjects and the patients with mitral stenosis and chronic bronchitis in the literature. In conclusion, our continuum model can be used to predict the changes of steady flow in human pulmonary circulation.
ISSN: 1556-5297
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