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Title: Defocus Incorporated Soft Contact (DISC) lens slows myopia progression in Hong Kong Chinese school children : A 2-year randomised clinical trial
Authors: Lam, CSY 
Tang, WC
Tse, DYY
Tang, YY
To, CH 
Issue Date: 2014
Publisher: BMJ Publishing Group
Source: British journal of ophthalmology, 2014, v. 98, no. 1, p. 40-45 How to cite?
Journal: British journal of ophthalmology 
Abstract: Aims: To determine if 'Defocus Incorporated Soft Contact' (DISC) lens wear slows childhood myopia progression. Methods: A 2-year double-blind randomised controlled trial was carried out in 221 children aged 8-13 years, with myopia between - 1.00 and -5.00 Dioptres (D) and astigmatism < 1.00 D. Subjects were randomly assigned to the DISC (n=111) or single vision (SV; n=110) contact lens group. DISC lenses incorporated concentric rings, which provided an addition of +2.50 D, alternating with the normal distance correction. Refractive error (cycloplegic autorefraction) and axial length were measured at 6-month intervals. Differences between groups were analysed using unpaired t test. Results: In total, 128 children completed the study, n=65 in the DISC group and n=63 in the SV group. Myopia progressed 25% more slowly for children in the DISC group compared with those in the control group (0.30 D/year; 95% CI - 0.71 to - 0.47 vs 0.4 D/year; 95% CI -0.93 to -0.65, p=0.031). Likewise, there was less axial elongation for children in the DISC versus SV groups (0.13 mm/year; 95% CI 0.20 to 0.31 vs 0.18 mm/year; 95% CI 0.30 to 0.43, p=0.009). Treatment effect correlated positively with DISC lens wearing time (r=0.342; p=0.005). Indeed, myopia in children who wore the DISC lenses for five or more hours/day progressed 46% (mean difference=-0.382 D, p=0.001; 95% CI -0.59 to -0.17) less than those in the SV group. Conclusions: The daily wearing of DISC lens significantly slowed myopia progression and axial elongation in Hong Kong schoolchildren. The findings demonstrated that simultaneous clear vision with constant myopic defocus can retard myopia progression.
ISSN: 0007-1161
EISSN: 1468-2079
DOI: 10.1136/bjophthalmol-2013-303914
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