Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29594
Title: An efficient chiral phosphorus derivatizing agent for the determination of the enantiomeric excess of chiral alcohols and amines by P-31 NMR spectroscopy
Authors: Li, KY
Zhou, ZH
Chan, ASC
Tang, CC
Issue Date: 2002
Publisher: John Wiley & Sons Inc
Source: Heteroatom chemistry, 2002, v. 13, no. 1, p. 93-95 How to cite?
Journal: Heteroatom Chemistry 
Abstract: The chiral phosphorus derivatizing agent (CDA) 1 was prepared from optically pure (S)-1,1-bis-2-naphthol. It was first used in the determination of the enantiomeric excess of chiral alcohols and amines by means of P-31 NMR spectroscopy. It showed that, for the chiral aromatic alcohols, no apparent kinetic resolution was noted and good base-line separation was observed. Furthermore, the chemical shift difference (Deltadelta) of P-31 NMR spectroscopy was much larger than those determined by the use of other chiral phosphorus derivatizing agents reported previously. However, for aliphatic alcohols, it showed not only obvious kinetic resolutions but incomplete base-line separation. Moreover, we also found that the use of CDA 1 was suitable for the determination of enantiomeric excess of chiral primary amines.
URI: http://hdl.handle.net/10397/29594
ISSN: 1042-7163
DOI: 10.1002/hc.10018
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