Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29400
Title: Performance of the VITEK MS matrix-assisted laser desorption ionization-time of flight mass spectrometry system for rapid bacterial identification in two diagnostic centres in China
Authors: Luo, Y
Siu, GKH
Yeung, ASF
Chen, JHK
Ho, PL
Leung, KW
Tsang, JLY
Cheng, VCC
Guo, L
Yang, J
Ye, L
Yam, WC
Issue Date: 2015
Publisher: Society for General Microbiology
Source: Journal of medical microbiology, 2015, v. 64, no. 1, p. 18-24 How to cite?
Journal: Journal of Medical Microbiology 
Abstract: Matrix-assisted laser desorption ionization-time of flight (MALDI-TOF) MS systems was not officially launched for diagnostic use in clinical microbiology laboratories in China until 2012. Here, we report the findings from the first large-scale evaluation study of VITEK MS for routine bacterial identification in two major diagnostic centres in Beijing and Hong Kong. A total of 2266 unique isolates representing 56 genera and 127 species were analysed, and results were compared to those obtained by VITEK 2. Any discrepancies were resolved by 16S rRNA sequencing. Overall, VITEK MS provided correct identification for 2246 (99.1%) isolates, including 2193 (96.8%) with correct species-level identifications and 53 (2.3%) matched at the genus level only. VITEK MS surpassed VITEK 2 consistently in species-level identification of important pathogens, including non-Enterobacteriaceae Gram-negative bacilli (94.7 versus 92%), staphylococci (99.7 versus 92.4%), streptococci (92.6 versus 79.4%), enterococci (98.8 versus 92.6%) and Clostridium spp. (97.3 versus 55.5%). The findings demonstrated that VITEK MS is highly accurate and reliable for routine bacterial identification in clinical settings in China.
URI: http://hdl.handle.net/10397/29400
ISSN: 0022-2615
DOI: 10.1099/jmm.0.080317-0
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