Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29309
Title: Development of Fe3O4-poly(l-lactide) magnetic microparticles in supercritical CO2
Authors: Chen, AZ
Kang, YQ
Pu, XM
Yin, GF
Li, Y
Hu, JY
Keywords: Fe3O4
Magnetic
Microparticles
PLLA
Supercritical CO2
Issue Date: 2009
Publisher: Academic Press Inc Elsevier Science
Source: Journal of colloid and interface science, 2009, v. 330, no. 2, p. 317-322 How to cite?
Journal: Journal of Colloid and Interface Science 
Abstract: The Fe3O4-poly(l-lactide) (Fe3O4-PLLA) magnetic microparticles were successfully prepared in a process of solution-enhanced dispersion by supercritical CO2 (SEDS), and their morphology, particle size, magnetic mass content, surface atom distribution and magnetic properties were characterized. Indomethacin (Indo) was used as a drug model to produce drug-polymer magnetic composite microparticles. The resulting Fe3O4-PLLA microparticles with mean size of 803 nm had good magnetic property and a saturation magnetization of 24.99 emu/g. The X-ray photoelectron spectroscopy (XPS) test indicated that most of the Fe3O4 were encapsulated by PLLA, which indicated that the Fe3O4-PLLA magnetic microparticles had a core-shell structure. After further loading with drug, the Indo-Fe3O4-PLLA microparticles had a bigger mean size of 901 nm, and the Fourier transform infrared spectrometer (FTIR) analysis demonstrated that the SEDS process was a typical physical coating process to produce drug-polymer magnetic composite microparticles, which is favorable for drugs since there is no change in chemistry. The in vitro cytotoxicity test showed that the Fe3O4-PLLA magnetic microparticles had no cytotoxicity and were biocompatible, which means there is potential for biomedical application.
URI: http://hdl.handle.net/10397/29309
ISSN: 0021-9797
DOI: 10.1016/j.jcis.2008.10.085
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