Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29296
Title: Development of core-shell microcapsules by a novel supercritical CO2 process
Authors: Chen, AZ
Li, Y 
Chen, D
Hu, JY
Issue Date: 2009
Publisher: Springer
Source: Journal of materials science : materials in medicine, 2009, v. 20, no. 3, p. 751-758 How to cite?
Journal: Journal of materials science : materials in medicine 
Abstract: 5-fluorouracil-SiO2-poly(L-lactide) (5-Fu-SiO2-PLLA) microcapsules were prepared in a novel process of solution-enhanced dispersion by supercritical CO2 (SEDS). The SiO2 nanoparticles were loaded with 5-Fu by adsorption at the first place, then the 5-Fu-SiO2 nanoparticles were coated with PLLA by a modified SEDS process. The resulted microcapsules were characterized by scanning electron microscope (SEM), laser diffraction particle size analyzer, Fourier transform infrared spectrometer (FTIR) and thermogravimeter-differential scanning calorimeter (TG-DSC). The drug load, encapsulation efficiency and drug release profiles were also determined. The resulted microcapsules exhibited a rather spherical shape, smooth surface, and a narrow particle size distribution with a mean particle size of 536 nm. The drug load and encapsulation efficiency of the samples were 0.18% and 80.53%, respectively, 25.05% of 5-Fu was released in the first half hour, then drug released in a sustained process, which was much slower than that of without coated by PLLA. The results indicated that the modified SEDS process could be used to produce drug-polymer microcapsules with a core-shell structure, high encapsulation efficiency and sustained drug release effect.
URI: http://hdl.handle.net/10397/29296
ISSN: 0957-4530
DOI: 10.1007/s10856-008-3633-9
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