Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29197
Title: Antioxidant power of angiotensin-converting enzyme inhibitors in vitro
Authors: Benzie, IFF 
Tomlinson, B
Keywords: ACE inhibitor
Antioxidant
Captopril
CHD
FRAP assay
Hypertension
Oxidative stress
ROS
Issue Date: 1998
Publisher: Wiley-Blackwell
Source: British journal of clinical pharmacology, 1998, v. 45, no. 2, p. 168-169 How to cite?
Journal: British journal of clinical pharmacology 
Abstract: Aims. There is controversy regarding the potential antioxidant effect of captopril, therefore this study was performed to compare the in vitro antioxidant power of captopril with other angiotensin-converting enzyme (ACE) inhibitors. Methods. Antioxidant power of captopril, enalapril, fosinopril, perindopril, quinapril and ramipril in aqueous solution was measured using the ferric reducing (antioxidant) power (FRAP) assay; captopril was also measured in ethanolic solution. Results. Only captopril showed significant antioxidant power, demonstrating a stoichiometric factor of 1.0 in this assay. Concentration-related antioxidant power was seen in both aqueous and ethanolic solutions. Conclusions. Captopril shows antioxidant activity in vitro. This property could be relevant in vivo if captopril is concentrated in membranes, lipoproteins or at other important sites.
URI: http://hdl.handle.net/10397/29197
ISSN: 0306-5251
EISSN: 1365-2125
DOI: 10.1046/j.1365-2125.1998.00664.x
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