Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29195
Title: Altered immune function associated with disordered neural connectivity and executive dysfunctions : a neurophysiological study on children with autism spectrum disorders
Authors: Han, YMY
Chan, AS
Sze, SL
Cheung, MC
Wong, CK
Lam, JMK
Poon, PMK
Keywords: Autism
Children
EEG coherence
Executive dysfunction
Immunologic function
Issue Date: 2013
Publisher: Elsevier Sci Ltd
Source: Research in autism spectrum disorders, 2013, v. 7, no. 6, p. 662-674 How to cite?
Journal: Research in Autism Spectrum Disorders 
Abstract: Previous studies have shown that children with autism spectrum disorders (ASDs) have impaired executive function, disordered neural connectivity, and abnormal immunologic function. The present study examined whether these abnormalities were associated. Seventeen high-functioning (HFA) and 17 low-functioning (LFA) children with ASD, aged 8-17 years, participated voluntarily in the study. The two groups of children were compared on their general intelligence in terms of IQ; executive function as measured by the Hong Kong List Learning Test, D2 Test of Concentration, Five Point Test, Children's Color Trail Test, Tower of California Test, and Go/No-Go task; a non-executive task as measured by the Picture Completion Task; neural connectivity as measured by theta coherence in the anterior and posterior regions; and immunologic function as measured by the level of circulating CD3+ CD8+ suppressor/cytotoxic T lymphocytes in a blood sample. Results on executive function showed that LFA children performed significantly poorer than HFA children as shown on their lower Executive Composite as well as individual executive function scores. However, there was no group difference on the Picture Completion Task. Results on neural connectivity showed that LFA children demonstrated a different pattern of electroencephalography (EEG) coherence from HFA children as shown in the significantly elevated theta coherence in the anterior network, as well as at the left intra-hemispheric (LA-LP) and right-to-left inter-hemisphere (RA-LP) connections of LFA children. In immunologic function, results showed that LFA children had significantly elevated level of suppressor/cytotoxic T lymphocytes (CD3+ CD8+) (p < 0.05). In addition, the executive dysfunction, disordered neural connectivity, and abnormal immunologic function were found to be associated. These results provided some initial evidence to support the notion that immunologic factors are associated with neuronal damage, measureable by EEG coherence and manifested as executive dysfunctions.
URI: http://hdl.handle.net/10397/29195
ISSN: 1750-9467
DOI: 10.1016/j.rasd.2013.02.011
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

7
Last Week
0
Last month
2
Citations as of Oct 10, 2017

WEB OF SCIENCETM
Citations

7
Last Week
0
Last month
Citations as of Oct 21, 2017

Page view(s)

44
Last Week
1
Last month
Checked on Oct 15, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.