Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/29128
Title: Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice
Authors: Kuang, X
Yao, Y
Du, JR
Liu, YX
Wang, CY
Qian, ZM
Keywords: Cell apoptosis
Forebrain cerebral ischemia (FCI), Z-ligustilide
Neuroprotection
Oxidative damage
Issue Date: 2006
Source: Brain research, 2006, v. 1102, no. 1, p. 145-153 How to cite?
Journal: Brain Research 
Abstract: Radix Angelica sinensis, known as Danggui in Chinese, has been used to treat cardiovascular and cerebrovascular diseases in Traditional Chinese Medicine for a long time. Modern phytochemical studies showed that Z-ligustilide (LIG) is the main lipophilic component of Danggui. In this study, we examined whether LIG could protect ischemia/reperfusion-induced brain injury by minimizing oxidative stress and anti-apoptosis. Transient forebrain cerebral ischemia (FCI) was induced by the bilateral common carotid arteries occlusion for 30 min. LIG was intraperitoneally injected to ICR mice at the beginning of reperfusion. As determined via 2,3,5-triphenyl tetrazolium chloride (TTC) staining at 24 h following ischemia, the infarction volume in the FCI mice treated without LIG (22.1 ± 2.6%) was significantly higher than that in the FCI mice treated with 5 mg/kg (11.8 ± 5.2%) and 20 mg/kg (2.60 ± 1.5%) LIG (P < 0.05 or P < 0.01). LIG treatment significantly decreased the level of malondialdehyde (MDA) and increased the activities of the antioxidant enzyme glutathione peroxidase (GSH-PX) and superoxide dismutase (SOD) in the ischemic brain tissues (P < 0.05 or P < 0.01 vs. FCI group). In addition, LIG provided a great increase in Bcl-2 expression as well as a significant decrease in Bax and caspase-3 immunoreactivities in the ischemic cortex. The findings demonstrated that LIG could significantly protect the brain from damage induced by transient forebrain cerebral ischemia. The antioxidant and anti-apoptotic properties of LIG may contribute to the neuroprotective potential of LIG in cerebral ischemic damage.
URI: http://hdl.handle.net/10397/29128
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2006.04.110
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

101
Last Week
1
Last month
0
Citations as of Jan 21, 2017

WEB OF SCIENCETM
Citations

87
Last Week
1
Last month
2
Citations as of Jan 15, 2017

Page view(s)

17
Last Week
0
Last month
Checked on Jan 22, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.