Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28873
Title: La3+-promoted proliferation is interconnected with apoptosis in NIH 3T3 cells
Authors: Yu, S
Yuan, L
Yang, X
Wang, K
Ke, Y
Qian, ZM
Keywords: Apoptosis
Cell cycle
ERK
La3+
Proliferation
Issue Date: 2005
Source: Journal of cellular biochemistry, 2005, v. 94, no. 3, p. 508-519 How to cite?
Journal: Journal of Cellular Biochemistry 
Abstract: Lanthanum ion (La3+) has been reported to affect proliferation or apoptosis of different cells. In the present study, La3+ was confirmed to promote both proliferation and apoptosis of NIH 3T3 cells at the same concentrations. La3+ was shown to promote proliferation by helping the cells to pass through the G1/S restriction point and enter S phase, however, the proliferating cells induced by incubation with La3+ eventually underwent apoptosis. The proliferation and apoptosis of NIH 3T3 cells induced by La3+ were well correlated with cell cycle alterations. La3+ caused the phosphorylation of extracellular signal-regulated kinase (ERK) 1/2; while inhibition of ERK phosphorylation by 2′-amino-3′-methoxyflavone (PD98059) suppressed both proliferation and apoptosis induced by La3+. Based on the above experimental results, we postulated that La3+-promoted proliferation of NIH 3T3 cells could be interconnected with the cell apoptosis, possibly through cell cycle machinery. Our results thus support the recent hypothesis that proliferation and apoptosis of cell are intrinsically coordinated.
URI: http://hdl.handle.net/10397/28873
ISSN: 0730-2312
DOI: 10.1002/jcb.20303
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