Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28850
Title: Fabrication of antibacterial silicone composite by an antibacterial agent deposition, solution casting and crosslinking technique
Authors: Tang, CY 
Chen, DZ
Chan, KYY
Chu, KM
Ng, PC
Yue, TM 
Keywords: Antibacterial activity
Composite
Silicone
Silver-containing sodium zirconium phosphate
Issue Date: 2011
Publisher: John Wiley & Sons
Source: Polymer international, 2011, v. 60, no. 10, p. 1461-1466 How to cite?
Journal: Polymer international 
Abstract: The key problems faced in developing indwelling catheters are how to incorporate antibacterial agents into the substrate and how to improve the antibacterial effectiveness. In this study, an antibacterial composite coating layer is inversely in situ formed on the silicone substrate by a novel technique involving deposition of an antibacterial agent, solution casting and crosslinking of a silicone resin. The antibacterial particles were strongly bonded to the matrix silicone and evenly dispersed on the coating surface. Moreover, energy-dispersive X-ray analysis revealed the gradient distribution of the antibacterial agent, perpendicular to the composite surface. The co-instantaneous crosslinking within the coating layer and polymer substrate as well as the graded structure formed lead to good adhesion between the two parts. The silicone composite shows a highly efficient antibacterial activity with no cytotoxicity to HL-60 cells. Compared with the commonly used methods of incorporating antibacterial agents into the silicone substrate, such as multiple dip-coating, surface grafting or simple blending, the proposed process is easily operated and is promising for forming a percutaneous or subcutaneous device with the capacity for efficient sterilization in an economical way.
URI: http://hdl.handle.net/10397/28850
ISSN: 0959-8103
EISSN: 1097-0126
DOI: 10.1002/pi.3102
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