Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28845
Title: Spectroscopic studies of DNA binding modes of cation-substituted anthrapyrazoles derived from emodin
Authors: Tan, JH
Lu, YJ
Huang, ZS
Gu, LQ
Wu, JY 
Keywords: Amino side chain
Anthrapyrazole
DNA binding
Emodin
Spectroscopic analysis
Issue Date: 2007
Publisher: Elsevier Masson
Source: European journal of medicinal chemistry, 2007, v. 42, no. 9, p. 1169-1175 How to cite?
Journal: European journal of medicinal chemistry 
Abstract: The DNA binding properties of three cation-substituted anthrapyrazole derivatives of emodin with calf thymus DNA were characterized by spectroscopic methods and the specific binding modes were elucidated. At low drug and high DNA concentrations, compound 1 with a mono-cationic amino side chain exhibited an intercalative binding mode, 2 with a much longer and more flexible di-cationic side chain exhibited an external binding mode, and 3 with a rigid di-cationic side chain exhibited both intercalative and external binding modes. The DNA binding mode of compounds was altered after structural modification. The molecular structure-DNA binding relationships found from this study may be useful for the design of anthrapyrazole derivatives with desired binding characteristics.
URI: http://hdl.handle.net/10397/28845
ISSN: 0223-5234
EISSN: 1768-3254
DOI: 10.1016/j.ejmech.2007.02.002
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