Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28816
Title: Development of phyllanthin containing microcapsules and their improved biological activity towards skin cells and Staphylococcus aureus
Authors: Lam, PL
Gambari, R
Yip, J
Yuen, MCW
Lam, KH
Wong, RSM
Wang, XW
Tang, JCO 
Kok, SHL
Chui, CH
Keywords: Chitosan
Human skin cells
Microcapsule
Phyllanthin
Staphylococcus aureus
Issue Date: 2012
Publisher: Pergamon Press
Source: Bioorganic & medicinal chemistry letters, 2012, v. 22, no. 1, p. 468-471 How to cite?
Journal: Bioorganic & medicinal chemistry letters 
Abstract: Chitosan based microcapsule which encapsulated with phyllanthin was developed by simple coacervation. The composition and surface morphology of phyllanthin containing microcapsules were analyzed by Fourier Transform Infrared spectroscopy and Scanning Electron Microscopy, respectively. The release of phyllanthin from the microcapsules was found to be more than 60% after 120 h. In vitro biological assays demonstrated that these phyllanthin containing microcapsules showed a stronger anti-oxidation potential on both human fibroblasts and keratinocytes as well as a better growth inhibitory activity towards Staphylococcus aureus.
URI: http://hdl.handle.net/10397/28816
ISSN: 0960-894X
EISSN: 1464-3405
DOI: 10.1016/j.bmcl.2011.10.097
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