Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28535
Title: Two novel species of tetrodotoxin-producing bacteria isolated from toxic marine puffer fishes
Authors: Yu, CF
Yu, PHF
Chan, PL
Yan, Q
Wong, PK
Keywords: Mouse bioassay
Tetrodotoxin
Tetrodotoxin-producing bacteria
Issue Date: 2004
Source: Toxicon, 2004, v. 44, no. 6, p. 641-647 How to cite?
Journal: Toxicon 
Abstract: Out of eight dominant discrete bacterial colonies isolated and purified from the toxic marine puffer fishes collected in Hong Kong waters, two novel species of non-sporing, non-acid-fast and chemoorganotrophic bacteria capable of producing tetrodotoxin (TTX, a potent non-protein neurotoxin), as well as one previously reported and confirmed TTX-producing bacterium. They were identified as Microbacterium arabinogalactanolyticum, Serratia marcescens and Vibrio alginolyticus, respectively, all of which are widely distributed in soils, sewage or marine environments. Each bacterial isolate (500 ml broth medium cultured in darkness without aeration for 10 days at 25°C) could produce an amount of toxicity, after extraction and purification, ranging from 78.3 to 105.3 mouse units (MU) in 500 ml of broth medium by mouse bioassay. The principal toxic component in the bacterial cultures was determined to be TTX by thin layer chromatography and mass spectrometry.
URI: http://hdl.handle.net/10397/28535
ISSN: 0041-0101
DOI: 10.1016/j.toxicon.2004.07.021
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