Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28427
Title: Synthesis of 5-(7-hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide, a core functionality of antibiotic leinamycin
Authors: Lee, AHF
Chan, ASC
Li, T
Keywords: 1,2-dithiolan-3-one 1-oxide
Activated ester
Antibiotic leinamycin
Antisense oligonucleotide
DNA-cleaving agent
Heterocycle
Issue Date: 2003
Publisher: Pergamon Press
Source: Tetrahedron, 2003, v. 59, no. 6, p. 833-839 How to cite?
Journal: Tetrahedron 
Abstract: 5-(7-Hydroxyhept-3-enyl)-1,2-dithiolan-3-one 1-oxide 1 possessing both the 1,2-dithiolan-3-one 1-oxide five-membered ring and the double bond at the gamma position of the heterocycle, characteristic of the antibiotic leinamycin, was synthesized. In addition, the activated ester form of 1 was prepared that may be useful for coupling 1 to certain DNA-binding agents.
URI: http://hdl.handle.net/10397/28427
ISSN: 0040-4020
DOI: 10.1016/S0040-4020(02)01600-9
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