Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28400
Title: Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs
Authors: Huo, C
Yang, H
Cui, QC
Dou, QP
Chan, TH
Issue Date: 2010
Publisher: Pergamon-Elsevier Science Ltd
Source: Bioorganic and medicinal chemistry, 2010, v. 18, no. 3, p. 1252-1258 How to cite?
Journal: Bioorganic and Medicinal Chemistry 
Abstract: A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT.
URI: http://hdl.handle.net/10397/28400
DOI: 10.1016/j.bmc.2009.12.034
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