Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28378
Title: L-DOPA oxidation products prevent H2O2-induced oxidative damage to cellular DNA
Authors: Shi, YL
Benzie, IFF 
Buswell, JA
Keywords: Genoprotection
L-DOPA
Oxidative damage
Reactive oxygen species
Tyrosinase
Issue Date: 2002
Source: Life sciences, 2002, v. 71, no. 26, p. 3047-3057 How to cite?
Journal: Life Sciences 
Abstract: Using the single-cell gel electrophoresis ("Comet") assay, we show that tyrosinase-generated L-DOPA oxidation products prevent H2O2-induced oxidative DNA damage in cultured tissue cells. We propose that these oxidation products trigger cellular processes that up-regulate the overall antioxidant status of the cell, and could be incorporated into treatments of pathological conditions associated with elevated oxidative DNA damage and other manifestations of increased oxidative stress.
URI: http://hdl.handle.net/10397/28378
ISSN: 0024-3205
DOI: 10.1016/S0024-3205(02)02172-0
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