Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28306
Title: Genistein protects primary cortical neurons from iron-induced lipid peroxidation
Authors: Ho, KP
Li, L
Zhao, L
Qian, ZM
Keywords: Genistein
Iron
Primary cortical neurons
SD rats
Superoxide dismutase
Thiobarbituric-acid-reactive species
Issue Date: 2003
Publisher: Kluwer Academic Publ
Source: Molecular and cellular biochemistry, 2003, v. 247, no. 1-2, p. 219-222 How to cite?
Journal: Molecular and Cellular Biochemistry 
Abstract: Neuroprotective role of isoflavones in particular genistein might be resulted from their antioxidant activities in addition to their estrogenic actions. In the present study, we investigated effect of genistein on iron-induced free radical reaction in cultured cortical neurons. Thiobarbituric-acid-reactive species (TBARS) and superoxide dismutase (SOD) were measured after incubation of the cells with different concentrations of genistein in the absence or presence of iron (12.5 μM) for 24 h. Genistein at 100 μM significantly reduced the iron-induced TBARS, implying that genistein has an inhibitory role on iron-induced lipid peroxidation. Also, genistein (100 μM) led to a relatively higher SOD level than that in iron treatment although no significant difference was found. The findings imply that the antioxidative effect of genistein is partly associated with its neuroprotective function.
URI: http://hdl.handle.net/10397/28306
ISSN: 0300-8177
DOI: 10.1023/A:1024142004575
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