Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/28159
Title: Electroacupuncture reduces the extent of lipid peroxidation by increasing superoxide dismutase and glutathione peroxidase activities in ischemic-reperfused rat brains
Authors: Siu, FKW
Lo, SCL 
Leung, MCP
Keywords: Cerebral ischemia
Electroacupuncture
Glutathione peroxidase
Lipid peroxidation
Superoxide dismutase
Issue Date: 2004
Publisher: Elsevier
Source: Neuroscience letters, 2004, v. 354, no. 2, p. 158-162 How to cite?
Journal: Neuroscience letters 
Abstract: Reactive oxygen species can be scavenged by superoxide dismutase (SOD) and glutathione peroxidase (GPx). During ischemia-reperfusion, the normal functioning of these antioxidant enzymes may be insufficient for the prevention of oxidant-induced peroxidation of membrane lipids and hence cerebral infarction. We therefore investigated whether electroacupuncture (EA) treatment at Fengchi points in post-ischemic rats could increase the antioxidant enzyme activities and thereby reduce the extent of lipid peroxidation. The results indicated that while EA did not alter the antioxidant enzyme activities in non-ischemic normal rat brains, ischemia-reperfusion caused significant increases in SOD and GPx activities. EA treatment further increased the antioxidant enzyme activities in ischemic-reperfused brain tissues, with a concomitant decrease in the extent of lipid peroxidation. Our finding suggests that EA treatment at Fengchi reduced the extent of lipid peroxidation in ischemic-reperfused rat brains, possibly by increasing the activities of SOD and GPx.
URI: http://hdl.handle.net/10397/28159
ISSN: 0304-3940
EISSN: 1872-7972
DOI: 10.1016/j.neulet.2003.10.009
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