Please use this identifier to cite or link to this item:
Title: Pancreatic beta-cell function and type 2 diabetes risk : quantify the causal effect using a Mendelian randomization approach based on meta-analyses
Authors: Song, Y
Yeung, E
Liu, A
VanderWeele, TJ
Chen, L
Lu, C
Liu, C 
Schisterman, EF
Ning, Y
Zhang, C
Issue Date: 2012
Publisher: Oxford Univ Press
Source: Human molecular genetics, 2012, v. 21, no. 22, dds339, p. 5010-5018 How to cite?
Journal: Human Molecular Genetics 
Abstract: The objective of the study is to quantify the causal effect of β-cell function on type 2 diabetes by minimizing residual confounding and reverse causation. We employed a Mendelian randomization (MR) approach using TCF7L2 variant rs7903146 as an instrument for lifelong levels of β-cell function. We first conducted two sets of meta-analyses to quantify the association of the TCF7L2 variant with the risk of type 2 diabetes among 55 436 cases and 106 020 controls from 66 studies by calculating pooled odds ratio (OR) and to quantify the associations with multiple direct or indirect measures of β-cell function among 35 052 non-diabetic individuals from 31 studies by calculating pooled mean difference. We further applied the method of MR to obtain the causal estimates for the effect of β-cell function on type 2 diabetes risk based on findings from the meta-analyses. The OR [95% confidence interval (CI)] was 0.87 (0.81-0.93) for each five unit increment in homeostasis model assessment of insulin secretion (HOMA-%B) (P = 3.0 × 10-5). In addition, for measures based on intravenous glucose tolerance test, ORs (95% CI) associated with type 2 diabetes risk were 0.24 (0.08-0.74) (P = 0.01) and 0.14 (0.04-0.48) (P = 0.002) for per 1 standard deviation increment in insulin sensitivity index and disposition index, respectively. Findings from the present study lend support to a causal role of pancreatic β-cell function itself in the etiology of type 2 diabetes.
DOI: 10.1093/hmg/dds339
Appears in Collections:Journal/Magazine Article

View full-text via PolyU eLinks SFX Query
Show full item record


Last Week
Last month
Citations as of Aug 6, 2018


Last Week
Last month
Citations as of Aug 16, 2018

Page view(s)

Last Week
Last month
Citations as of Aug 19, 2018

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.