Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27816
Title: Therapeutic ultrasound enhances medial collateral ligament repair in rats
Authors: Leung, MCP
Ng, GYF 
Yip, KK
Keywords: Healing
Ligament
TGF-β1
Therapeutic ultrasound
Issue Date: 2006
Publisher: Elsevier
Source: Ultrasound in medicine and biology, 2006, v. 32, no. 3, p. 449-452 How to cite?
Journal: Ultrasound in medicine and biology 
Abstract: The purpose of this study was to evaluate the effects of therapeutic ultrasound (US) on medial collateral ligament healing. A total of 36 3-month-old male Sprague-Dawley rats with transected medial collateral ligaments were studied. Subjects were given 5-min pulsed US therapy (duty cycle; one application in 4 ms; 1:4) daily with different durations (1 day, 5 days and 10 days) and intensities (0, 0.5 and 2.3 W/cm2). After each treatment, the level of transforming growth factor beta-1 (TGF- β1) of the ligament was measured. TGF-β1 was not detected in the 1-day group. In the 5-day and 10-day groups, the levels of TGF-β1 were significantly up-regulated in the high-dose subgroup (p < 0.05). The 10-day group also registered a significantly higher expression of TGF-β1 than did the 5-day group (p < 0.05). The present findings suggest that pulsed US therapy may enhance ligament repair by up-regulating the extent of TGF-β1 in a high-dose application. Long-term treatment with this therapy could obtain further improvement.
URI: http://hdl.handle.net/10397/27816
ISSN: 0301-5629
EISSN: 1879-291X
DOI: 10.1016/j.ultrasmedbio.2005.09.014
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