Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27741
Title: Effective protection of Terminalia catappa L. leaves from damage induced by carbon tetrachloride in liver mitochondria
Authors: Tang, X
Gao, J
Wang, Y
Fan, YM
Xu, LZ
Zhao, XN
Xu, Q
Qian, ZM
Keywords: Alanine aminotransferase
Aspartate aminotransferase
Lipid peroxidation
Mitochondrial Ca 2+ overload
Mitochondrial Ca2+-ATPase activity
Mitochondrial membrane potential
Terminalia catappa L.
Issue Date: 2006
Source: Journal of nutritional biochemistry, 2006, v. 17, no. 3, p. 177-182 How to cite?
Journal: Journal of Nutritional Biochemistry 
Abstract: The protective effects of chloroform extracts of Terminalia catappa L. leaves (TCCE) on carbon tetrachloride (CCl4)-induced liver damage and the possible mechanisms involved in the protection were investigated in mice. We found that increases in the activity of serum aspartate aminotransferase and alanine aminotransferase and the level of liver lipid peroxidation (2.0-fold, 5.7-fold and 2.8-fold) induced by CCl4 were significantly inhibited by oral pretreatment with 20, 50 or 100 mg/kg of TCCE. Morphological observation further confirmed the hepatoprotective effects of TCCE. In addition, the disruption of mitochondrial membrane potential (14.8%), intramitochondrial Ca2+ overload (2.1-fold) and suppression of mitochondrial Ca 2+-ATPase activity (42.0%) in the liver of CCl4-insulted mice were effectively prevented by pretreatment with TCCE. It can be concluded that TCCE have protective activities against liver mitochondrial damage induced by CCl4, which suggests a new mechanism of the hepatoprotective effects of TCCE.
URI: http://hdl.handle.net/10397/27741
ISSN: 0955-2863
DOI: 10.1016/j.jnutbio.2005.06.008
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