Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27706
Title: Synthetic studies of the HIV-1 protease inhibitive didemnaketals : stereocontrolled synthetic approach to the key mother spiroketals
Authors: Jia, YX
Wu, B
Li, X
Ren, SK
Tu, YQ
Chan, ASC
Kitching, W
Issue Date: 2001
Publisher: American Chemical Society
Source: Organic letters, 2001, v. 3, no. 6, p. 847-849 How to cite?
Journal: Organic letters 
Abstract: matrix presented The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1′R,1″R)-2(acetylhydroxymethyl)-4,10-dimethyl- 8(isopropenylhydroxymethyl)-1,7-dioxaspiro[5,5]-undecane (4a) and its C1″-epimer (4b), the key mother spiroketals of the HIV-1 protease inhibitive didemnaketals from the ascidian Didemnum sp., has been carried out through multisteps from the natural (R)-(+)-pulegone, which involved the diastereoselective construction of four chiral carbon centers(C-2, C-6, C-8, and C-1′) by intramolecular chiral induce.
URI: http://hdl.handle.net/10397/27706
ISSN: 1523-7060
EISSN: 1523-7052
DOI: 10.1021/ol007016e
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