Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27657
Title: Paeciloxanthone, a new cytotoxic xanthone from the marine mangrove fungus Paecilomyces sp. (Tree1-7)
Authors: Wen, L
Lin, YC
She, ZG
Du, DS
Chan, WL
Zheng, ZH
Keywords: HepG2 toxicity
Marine mangrove fungus
Paecilomyces sp.
Paeciloxanthone
Issue Date: 2008
Publisher: Taylor & Francis Ltd
Source: Journal of Asian natural products research, 2008, v. 10, no. 2, p. 133-137 How to cite?
Journal: Journal of Asian Natural Products Research 
Abstract: The metatrophic fungus Paecilomyces sp. (Tree1-7) was isolated from an estuarine mangrove from the Taiwan Strait. The methanol extract of the fungal mycelium exhibited cytotoxicity against hepG2. Paeciloxanthone (1), a new xanthone, and the known compounds emodin (2) and chrysophanol (3), were isolated from the extract. Their structures were elucidated by spectroscopic experiments. Paeciloxanthone (1) exhibited in vitro cytotoxicity against hepG2 (IC50 = 1.08 μg/mL), acetylcholineesterase (AChE) inhibitory (IC50 = 2.25 μg/mL) and antimicrobial activities.
URI: http://hdl.handle.net/10397/27657
DOI: 10.1080/10286020701273783
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