Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27555
Title: Regioselective direct c-3 arylation of imidazo[1,2- a ]pyridines with aryl tosylates and mesylates promoted by palladium-phosphine complexes
Authors: Choy, PY
Luk, KC
Wu, Y
So, CM
Wang, LL
Kwong, FY 
Issue Date: 2015
Publisher: American Chemical Society
Source: Journal of organic chemistry, 2015, v. 80, no. 3, p. 1457-1463 How to cite?
Journal: Journal of organic chemistry 
Abstract: Direct C-3 arylation of imidazo[1,2-a]pyridines with aryl tosylates and mesylates has been accomplished by employing palladium(II) acetate associated with SPhos (2-dicyclohexylphosphino-2¡¬,6¡¬-dimethoxybiphenyl) or L1 (2-(2-(diisopropylphosphino)phenyl)-1-methyl-1H-indole). This catalyst system can be applied to a wide range of aryl sulfonates and shows excellent C-3 regioselectivity of imidazo[1,2-a]pyridine. These results represent the first examples of using tosylate- and mesylate-functionalized arenes as the electrophile partners for this regioselective direct arylation.
URI: http://hdl.handle.net/10397/27555
ISSN: 0022-3263
EISSN: 1520-6904
DOI: 10.1021/jo502386w
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