Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27444
Title: Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery
Authors: Seto, SW
Lam, HY
Lau, WS
Au, ALS
Lam, TY
Chim, SSC
Ngai, SM
Chan, SW
Leung, TY
Yeung, JHK
Kong, SK
Leung, GPH
Lee, SMY
Kwan, YW
Keywords: 5-hydroxytryptamine
Monoamine oxidase
Preeclampsia
Umbilical artery
Issue Date: 2009
Publisher: Elsevier
Source: European journal of pharmacology, 2009, v. 605, no. 1-3, p. 129-137 How to cite?
Journal: European journal of pharmacology 
Abstract: We investigated the role(s) of monoamine oxidases (MAOs) on the altered 5-hydroxytryptamine (5-HT, serotonin)-induced tension development of the isolated umbilical artery of preeclamptic pregnancy of Chinese women. An enhanced 5-HT-induced tension development of the umbilical artery of preeclamptic pregnancy was observed when compared with that of normal pregnancy. The enhanced component of 5-HT-induced tension development was eradicated by clorgyline (a MAO-A inhibitor). Blockade of eNOS (endothelial isoform nitric oxide synthase) (N ?s-nitro-l-arginine methyl ester), 5-HT transporter (citalopram), 5-HT receptor subtypes (5HT 2B, SB 204741; 5-HT 2C, RS 102221; 5-HT 7, SB 269970), and endothelium denudation of the umbilical artery of normal pregnancy mimicked the enhanced 5-HT-induced tension development as observed in the preeclamptic tissues. In contrast, no apparent changes in 5-HT-induced tension development of the umbilical artery of preeclamptic pregnancy were observed with the same pharmacological manipulations. A decreased protein expression levels of MAO-A a
URI: http://hdl.handle.net/10397/27444
ISSN: 0014-2999
DOI: 10.1016/j.ejphar.2008.12.054
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