Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27404
Title: Guasha-induced hepatoprotection in chronic active hepatitis B : a case study
Authors: Chan, ST
Yuen, JWM 
Gohel, MDI
Chung, CP
Wong, HC
Kwong, KK
Keywords: Guasha
Heme oxygenase
Hepatitis
Human
Issue Date: 2011
Publisher: Elsevier Science Bv
Source: Clinica chimica acta, 2011, v. 412, no. 17-18, p. 1686-1688 How to cite?
Journal: Clinica Chimica Acta 
Abstract: Background: Heme oxygenase-1 (HO-1) has demonstrated hepatoprotective effect in animal hepatitis models. HO-1 was also reported to be upregulated with Guasha, an ancient therapeutic technique which applies instrument assisted press-stroking to treat many disorders. Methods: We report a case on the changes of liver function, plasma HO-1 and T-helper (Th) cytokine balance in a chronic active hepatitis B carrier before and after Guasha. The patient presented with increased activities of liver enzymes (ALT and AST), indicating inflammatory damage in liver before Guasha. Results: Forty-eight hours after receiving Guasha, the patient showed changes in a number of serum markers: a decline of liver enzymes (ALT and AST) indicating reduced chronic inflammation, an elevated plasma HO-1, and a modulation of T-helper (Th)1/Th2 balance. Conclusions: Guasha was shown to transiently reduce the inflammatory markers of liver injury in human, together with an enhancement of HO-1 which might be responsible for the hepatoprotective action.
URI: http://hdl.handle.net/10397/27404
DOI: 10.1016/j.cca.2011.05.009
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