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Title: The longitudinal orthokeratology research in children (LORIC) in Hong Kong : a pilot study on refractive changes and myopic control
Authors: Cho, P 
Cheung, SW
Edwards, M
Keywords: Axial length
Eye elongation
Myopia progression
Myopia reduction
Issue Date: 2005
Publisher: Taylor & Francis
Source: Current eye research, 2005, v. 30, no. 1, p. 71-80 How to cite?
Journal: Current eye research 
Abstract: Purpose: Myopia is a common ocular disorder, and progression of myopia in children is of increasing concern. Modern overnight orthokeratology (ortho-k) is effective for myopic reduction and has been claimed to be effective in slowing the progression of myopia (myopic control) in children, although scientific evidence for this has been lacking. This 2 year pilot study was conducted to determine whether ortho-k can effectively reduce and control myopia in children. Methods: We monitored the growth of axial length (AL) and vitreous chamber depth (VCD) in 35 children (7-12 years of age), undergoing ortho-k treatment and compared the rates of change with 35 children wearing single-vision spectacles from an earlier study (control). For the ortho-k subjects, we also determined the changes in corneal curvature and the relationships with changes of refractive errors, AL and VCD. Results: The baseline spherical equivalent refractive errors (SER), the AL, and VCD of the ortho-k and control subjects were not statistically different. All the ortho-k subjects found post-ortho-k unaided vision acceptable in the daytime. The residual SER at the end of the study was -0.18 ± 0.69 D (dioptre) and the reduction (less myopic) in SER was 2.09 ± 1.34 D (all values are mean ± SD). At the end of 24 months, the increases in AL were 0.29 ± 0.27 mm and 0.54 ± 0.27 mm for the ortho-k and control groups, respectively (unpaired t test; p = 0.012); the increases in VCD were 0.23 ± 0.25 mm and 0.48 ± 0.26 mm for the ortho-k and control groups, respectively (p = 0.005). There was significant initial corneal flattening in the ortho-k group but no significant relationships were found between changes in corneal power and changes in AL and VCD. Conclusion: Ortho-k can have both a corrective and preventive/control effect in childhood myopia. However, there are substantial variations in changes in eye length among children and there is no way to predict the effect for individual subjects.
ISSN: 0271-3683
EISSN: 1460-2202
DOI: 10.1080/02713680590907256
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