Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/27133
Title: Effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice with and without the influence of fenofibrate
Authors: Pan, SY
Dong, H
Guo, BF
Zhang, Y
Yu, ZL
Fong, WF
Han, YF 
Ko, KM
Keywords: Fatty liver
Fenofibrate
Hepatomegaly
Hypertriglyceridemia
Schisandrin B
Total cholesterol
Issue Date: 2011
Publisher: Springer
Source: Naunyn-schmiedeberg's archives of pharmacology, 2011, v. 383, no. 6, p. 585-591 How to cite?
Journal: Naunyn-Schmiedeberg's Archives of Pharmacology 
Abstract: Schisandrin B, an active ingredient isolated from the fruit of Schisandra chinensis, increased serum and hepatic triglyceride levels in mice. In the present study, the effective kinetics of schisandrin B on serum/hepatic triglyceride and total cholesterol levels in mice without and with the influence of fenofibrate were investigated. Parameters on hepatic index (the ratio of liver weight to body weight × 100) were also analyzed. Mice were intragastrically treated with schisandrin B at a single dose of 0.2, 0.4, 0.8, or 1.6 g/kg, without or with fenofibrate pretreatment (0.1 g/kg/day for 4 days, p.o.). Twenty-four hours after schisandrin B treatment, serum/hepatic triglyceride and total cholesterol levels were measured. Schisandrin B treatment dose-dependently increased serum and hepatic triglyceride levels as well as hepatic index in mice. In contrast, hepatic total cholesterol levels were decreased in a dose-dependent manner in schisandrin B-treated mice. Data obtained from effective kinetics analysis indicated that the action of schisandrin B on serum triglyceride had a higher specificity than those on hepatic total cholesterol and hepatic index. While fenofibrate pretreatment inhibited the schisandrin B-induced elevation in serum triglyceride levels, it completely abrogated the elevation of hepatic triglyceride levels in schisandrin B-treated mice. The combined treatment with schisandrin B and fenofibrate decreased hepatic total cholesterol level and increased the hepatic index in an additive or semi-additive manner, respectively. In conclusion, the results of effective kinetics analysis indicated that the schisandrin B-induced hypertriglyceridemia was competitively inhibited by fenofibrate. Schisandrin B may offer the prospect of setting up a mouse model of hypertriglyceridemia and fatty liver for screening triglyceride-lowering drug candidates.
URI: http://hdl.handle.net/10397/27133
DOI: 10.1007/s00210-011-0634-x
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

14
Last Week
0
Last month
0
Citations as of Oct 11, 2017

WEB OF SCIENCETM
Citations

13
Last Week
1
Last month
Citations as of Oct 14, 2017

Page view(s)

36
Last Week
0
Last month
Checked on Oct 15, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.