Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26993
Title: Activities of fresh juice of Scutellaria barbata and warmed water extract of Radix Sophorae Tonkinensis on anti-proliferation and apoptosis of human cancer cell lines
Authors: Chui, C.H.
Lau, FY
Tang, JCO 
Kan, KL
Cheng, GYM
Wong, RSM
Kok, SHL
Lai, PBS
Ho, R
Gambari, R
Chan, ASC
Keywords: Scutellaria barbata
Radix Sophorae Tonkinensis
Herbal medicines
Issue Date: 2005
Publisher: Spandidos Publications
Source: International journal of molecular medicine, 2005, v. 16, no. 2, p. 337-341 How to cite?
Journal: International journal of molecular medicine 
Abstract: The possible antiproliferative and apoptotic inducing potentials of fresh juice prepared from Scutellaria barbata (SBJ) and warmed water extract of Radix Sophorae Tonkinensis (RSTE) have been tested on a series of cancer cell lines, including HepG2 hepatoblastoma, Hep3B hepatocellular carcinoma, MDA-MB231 breast carcinoma, A549 lung cancer and KG-I acute myelogenous leukaemia in vitro. Both SBJ and RSTE were able to inhibit the growth of cancer cell lines and induce apoptosis. Further analysis of the action of RSTE on HepG2 cells suggested that the activity of the central machinery of apoptosis, caspase 3, was significantly elevated. Oligo-nucleosomal length DNA fragments formation was readily detected by TdT-mediated dUTP nick end labelling assay after RSTE treatment. Taken together, we believe that, although Radix Sophorae Tonkinensis was demonstrated to have toxic components including matrine and oxymatrine, it is still worthwhile to further investigate its anti-cancer potential under a safety toxicological precaution.
URI: http://hdl.handle.net/10397/26993
ISSN: 1107-3756
EISSN: 1791-244X
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