Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26986
Title: Suppression of diet-induced hypercholesterolaemia by saponins from Panax notoginseng in rats
Authors: Wu, JH
Leung, GPH
Kwan, YW
Sham, TT
Tang, JY
Wang, YH
Wan, JB
Lee, SMY
Chan, SW
Keywords: Cholesterol
Hypercholesterolaemia
Panax notoginseng
Rat
Saponin
Issue Date: 2013
Publisher: Elsevier Science Bv
Journal: Journal of Functional Foods 
Abstract: Panax notoginseng saponins (PNS) are major active constituents of P. notoginseng. This study investigated the mechanisms of the hypocholesterolaemic and atheroscleroprotective effects of PNS. It was found that treatment of PNS (30 or 100 mg/kg/day, p.o.) could significantly reduce elevated serum total cholesterol, triacylglycerol, low-density lipoprotein cholesterol and atherogenic index induced by feeding rats with high cholesterol diet for 28 days. High-density lipoprotein cholesterol could also be increased by PNS treatment. Additionally, PNS significantly enhanced the hypercholesterolaemia-induced reduction of superoxide dismutase activity in the liver. In hypercholesterolaemic rats, PNS significantly improved the endothelium-dependent vasodilatation, acetylcholine-induced nitric oxide production and endothelial nitric oxide synthase mRNA expression in a dose-dependent manner. It also significantly reversed the hypercholesterolaemia-induced changes in mRNA expressions of cholesterol 7α-hydroxylase and peroxisome proliferator-activated receptor α but not HMG-CoA reductase. The findings provided evidence for using PNS to prevent the development of hypercholesterolaemia and atherosclerosis. The hypocholesterolaemic activity of PNS is likely to be resulted from inducing the biosynthesis of bile acids from cholesterol and promoting the β-oxidation of fatty acids in the liver. The vasoprotective function of PNS may be brought about by increasing the gene expression of eNOS in endothelial cells, its antioxidative activity, or both.
URI: http://hdl.handle.net/10397/26986
ISSN: 1756-4646
DOI: 10.1016/j.jff.2013.03.013
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

24
Last Week
0
Last month
0
Citations as of Apr 12, 2018

WEB OF SCIENCETM
Citations

20
Last Week
0
Last month
0
Citations as of Apr 18, 2018

Page view(s)

67
Last Week
2
Last month
Citations as of Apr 23, 2018

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.