Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26961
Title: Chiral monoaminoalcohols and diaminoalcohols of squaric acid: New catalysts for the asymmetric reduction of ketones by borane
Authors: Zhou, H
Lu, S
Xie, R
Chan, ASC
Yang, TK
Issue Date: 2001
Source: Tetrahedron letters, 2001, v. 42, no. 6, p. 1107-1110
Abstract: Two series of new chiral ligands, squaric acid aminoalcohols and C2-symmetric squaric acid diaminoalcohols have been synthesized. The chiral oxazaborolidines formed in situ from these ligands have been used in the enantioselective borane reduction of prochiral ketones and diketones to afford alcohol products with up to 99% enantiomeric excesses. The structures of the ligands have an obvious effect on the ee of the resulting alcohols.
Keywords: Aminoalcohol and diaminoalcohol derivatives of squaric acid
Enantioselective reduction
Ketones
Oxazaborolidines
Publisher: Pergamon Press
Journal: Tetrahedron letters 
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/S0040-4039(00)02162-6
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