Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26913
Title: Molecular dynamics simulation of a microvillus in a cross flow
Authors: Chen, XY
Liu, Y 
So, RMC 
Yang, JM
Keywords: Microvillus
Molecular dynamics
Issue Date: 2005
Publisher: World Scientific Publ Co Pte Ltd
Source: Modern physics letters b, 2005, v. 19, no. 28-29, p. 1643-1646 How to cite?
Journal: Modern Physics Letters B 
Abstract: One of the functions of microvilli in the microvessel endothelial glycocalyx is molecular filtering. The microvillus behaves as a mechanosensory system which may sense the fluid shear and drag forces. The permeability of small particles in microvessel is crucial for drug design and drug delivery. Therefore a better understanding of flow field around microvillus is important to simulate accurately the particle penetration in microvessel. Since the dimension of the microvilli is about ∼10 nm, the conventional Navier-Stokes equation may not be good enough to simulate the fluid flow in such microscale and nanoscale structures. Molecular dynamics (MD) simulation is a powerful method to simulate the fluid flow at the molecular level. As a first attempt, the microvillus is reduced as a two-dimensional cylinder which is in a cross flow. The detailed drag and lift together with flow field are obtained and compared with available data.
URI: http://hdl.handle.net/10397/26913
ISSN: 0217-9849
DOI: 10.1142/S0217984905010116
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