Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26878
Title: Highly enantioselective iridium-catalyzed hydrogenation of quinoline derivatives using chiral phosphinite H8-BINAPO
Authors: Lam, KH
Xu, L
Feng, L
Fan, QH
Lam, FL
Lo, WH 
Chan, ASC
Keywords: Asymmetric hydrogenation
Immobilization
Iridium
Phosphinite ligands
Poly(ethylene glycol) dimethyl ether
Quinoline
Issue Date: 2005
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2005, v. 347, no. 14, p. 1755-1758 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: The chiral diphosphinite H8-BINAPO derived from H8-BINOL has been used in the Ir-catalyzed asymmetric hydrogenation of quinolines, and high enantioselectivity (up to 97% ee) was obtained. Immobilization of the iridium catalyst in poly(ethylene glycol) dimethyl ether (DMPEG) is also discussed. With DMPEG/hexane biphasic system, better enantioselectivities were obtained as compared to those observed in aprotic organic solvents.
URI: http://hdl.handle.net/10397/26878
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.200505130
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