Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26871
Title: PEG modified BaGdF5:Yb/Er nanoprobes for multi-modal upconversion fluorescent, in vivo X-ray computed tomography and biomagnetic imaging
Authors: Zeng, S
Tsang, MK
Chan, CF
Wong, KL
Hao, J 
Keywords: Upconversion
Nanoparticle
Fluorecent bio-imaging
X-ray computed tomography
Magnetic property
Issue Date: 2012
Publisher: Elsevier Sci Ltd
Source: Biomaterials, 2012, v. 33, no. 36, p. 9232-9238 How to cite?
Journal: Biomaterials 
Abstract: Herein, a multi-functional nanoprobe of polyethylene glycol (PEG) modified BaGdF5:Yb/Er upconversion nanoparticles (UCNPs) for tri-modal bioimaging of fluorescence, computed X-ray tomography (CT), and magnetic application is demonstrated for the first time. The PEG-modified BaGdF5:Yb/Er UCNPs with optimal small size were synthesized by a facile one-pot hydrothermal method. The as-designed single-phase nanoprobe presents near-infrared to visible upconversion emissions in UC fluorescent bioimaging of HeLa cell. Importantly, we have demonstrated in vivo CT images with enhanced signals of spleen of a mouse for 2 h, indicating the UCNPs can be successfully used as CT contrast agent for improving the detection of splenic diseases. In addition, these UCNPs also exhibit excellent intrinsic paramagnetic property which can be also for magnetic imaging. Therefore, our results indicate that a tri-modal nanoprobe served as fluorescent/CT/magnetic bioimaging can be realized using the PEG-modified BaGdF5:Yb/Er UCNPs with very low cytotoxicity and long circulation time, which would be very useful in a variety of biomedical application fields.
URI: http://hdl.handle.net/10397/26871
ISSN: 0142-9612
DOI: 10.1016/j.biomaterials.2012.09.019
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

110
Citations as of Feb 12, 2016

WEB OF SCIENCETM
Citations

145
Last Week
0
Last month
3
Citations as of Aug 12, 2017

Page view(s)

43
Last Week
3
Last month
Checked on Aug 13, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.