Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26767
Title: A unique approach to the concise synthesis of highly optically active spirooxazolines and the discovery of a more potent oxindole-type phytoalexin analogue
Authors: Jiang, X
Cao, Y
Wang, Y
Liu, L
Shen, F
Wang, R
Issue Date: 2010
Publisher: Amer Chemical Soc
Source: Journal of the American chemical society, 2010, v. 132, no. 43, p. 15328-15333 How to cite?
Journal: Journal of the American Chemical Society 
Abstract: Drug-lead synthesis through rapid construction of chiral molecular complexity around the biologically relevant framework using a highly efficient strategy is a key goal of organic synthesis. Molecules bearing a spirooxindole-type framework exhibit important bioactivities. Herein, we present a highly efficient and convenient strategy that allows rapid construction of unique optically active spiro[oxazoline-3,3′-oxindole]s through the organocatalyzed asymmetric synthesis of spirocyclic thiocarbamates via an aldol reaction. Preliminary biological evaluation of several of the spirooxazolines using a model of acute neuroinflammation revealed promising antipyretic activity and provided an opportunity to discover new antipyretic agents.
URI: http://hdl.handle.net/10397/26767
DOI: 10.1021/ja106349m
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

202
Last Week
1
Last month
2
Citations as of Mar 18, 2017

WEB OF SCIENCETM
Citations

203
Last Week
1
Last month
0
Citations as of Mar 26, 2017

Page view(s)

20
Last Week
1
Last month
Checked on Mar 26, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.