Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26671
Title: Induction of apoptosis and cell cycle arrest in A549 human lung adenocarcinoma cells by surface-capping selenium nanoparticles : an effect enhanced by polysaccharide-protein complexes from Polyporus rhinocerus
Authors: Wu, H
Zhu, H
Li, X
Liu, Z
Zheng, W
Chen, T
Yu, B
Wong, KH 
Keywords: Apoptosis
Cell cycle arrest
Nanodrug
Selenium nanoparticles
Issue Date: 2013
Publisher: American Chemical Society
Source: Journal of agricultural and food chemistry, 2013, v. 61, no. 41, p. 9859-9866 How to cite?
Journal: Journal of agricultural and food chemistry 
Abstract: Surface-capping agents play key roles in cellular uptake and biological activity of functional nanomaterials. In the present study, functionalized selenium nanoparticles (SeNPs) have been successfully synthesized using Polyporus rhinocerus water-soluble polysaccharide-protein complexes (PRW) as the capping agent during the reduction of selenium salts. The acquired monodisperse, spherical PRW-SeNPs presented desirable size distribution and stability in the solution. Moreover, PRW surface decoration significantly enhanced the cellular uptake of SeNPs via endocytosis. Exposure to PRW-SeNPs significantly inhibited the growth of A549 cells through induction of apoptosis and G2/M phase arrest (IC50 = 4.06 ± 0.25 μM) supported by an increase of sub-G1 and G2/M phase cell populations, DNA fragmentation, and chromatin condensation. Caspase-3/8 activation induced by PRW-SeNPs indicated that the activation of death receptors was the main cause of PRW-SeNP-induced apoptosis. Collectively, the results suggest that it is highly efficient to use PRW as a surface decorator of SeNPs to enhance cellular uptake and anticancer efficacy, and the PRW-SeNPs are potential chemopreventive agents for lung cancer therapy.
URI: http://hdl.handle.net/10397/26671
ISSN: 0021-8561
DOI: 10.1021/jf403564s
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