Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26643
Title: Corticofugal projection inhibits the auditory thalamus through the thalamic reticular nucleus
Authors: Zhang, Z
Liu, CH
Yu, YQ
Fujimoto, K
Chan, YS
He, J
Issue Date: 2008
Publisher: Amer Physiological Soc
Source: Journal of neurophysiology, 2008, v. 99, no. 6, p. 2938-2945 How to cite?
Journal: Journal of Neurophysiology 
Abstract: Electrical stimulation of the auditory cortex (AC) causes both facilitatory and inhibitory effects on the medial geniculate body (MGB). The purpose of this study was to identify the corticofugal inhibitory pathway to the MGB. We assessed two potential circuits: 1) the cortico-colliculothalamic circuit and 2) cortico-reticulo-thalamic one. We compared intracellular responses of MGB neurons to electrical stimulation of the AC following bilateral ablation of the inferior colliculi (IC) or thalamic reticular nucleus (TRN) in anesthetized guinea pigs. Cortical stimulation with intact TRN could cause strong inhibitory effects on the MGB neurons. The corticofugal inhibition remained effective after bilateral IC ablation, but it was minimized after the TRN was lesioned with kainic acid. Synchronized TRN neuronal activity and MGB inhibitory postsynaptic potentials (IPSPs) were observed with multiple recordings. The results suggest that corticofugal inhibition traverses the corticoreticulothalamic pathway, indicating that the colliculi-geniculate inhibitory pathway is probably only for feedforward inhibition.
URI: http://hdl.handle.net/10397/26643
ISSN: 0022-3077
DOI: 10.1152/jn.00002.2008
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