Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26422
Title: Antitumor activity of diethynylfluorene derivatives of gold(I)
Authors: Chui, CH
Wong, RSM
Gambari, R
Cheng, GYM
Yuen, CWM
Chan, KW
Tong, SW
Lau, FY
Lai, PBS
Lam, KH
Ho, CL
Kan, CW 
Leung, KSY
Wong, WY
Keywords: Alkynes
Fluorenes derivatives
Gold(I) complexes
Human carcinoma cells
Nude mice model
Reactive oxygen species
Issue Date: 2009
Publisher: Pergamon-Elsevier Science Ltd
Source: Bioorganic and medicinal chemistry, 2009, v. 17, no. 23, p. 7872-7877 How to cite?
Journal: Bioorganic and Medicinal Chemistry 
Abstract: A list of diethynylfluorenes and their gold(I) derivatives have been studied for their antitumor activity as a function of their structure-activity relationships. End-capping the fluoren-9-one unit with gold(I) moieties could significantly strengthen the cytotoxic activity in vitro on three human cancer cell lines with induction of reactive oxygen species generation on Hep3B hepatocellular carcinoma cells and exhibit attractive antitumor activity from in vivo nude mice Hep3B xenograft model with limited adverse effects on vital organs including liver and kidney.
URI: http://hdl.handle.net/10397/26422
DOI: 10.1016/j.bmc.2009.10.034
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