Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26120
Title: Oriented and vectorial patterning of cardiac myocyte using a microfluidic dielectrophoresis chip - towards engineered cardiac tissue with controlled macroscopic anisotropy
Authors: Yang, M 
Lim, CC
Liao, R
Zhang, X
Keywords: Anisotropic magnetoresistance
Cardiac tissue
Dielectrophoresis
Electric fields
Electrodes
Frequency
Heart
Microelectrodes
Microfluidics
Torque
Issue Date: 2006
Publisher: IEEE
Source: 19th IEEE International Conference on Micro Electro Mechanical Systems, 2006 : MEMS 2006 Istanbul, 22-26 January 2006, Istanbul, Turkey, p. 8-11 How to cite?
Abstract: Recently, the ability to create engineered heart tissues with a preferential cell orientation has gained much interest. Here, we present a novel method to construct a cardiac myocyte tissue-like structure using a combination of dielectrophoresis and electro-orientation via a microfluidic chip. Using the interdigitated-castellated microelectrodes, the induction of a mutually attractive dielectrophoretic force between cardiac myocytes can lead the cells moving close to each other and forming a tissue-like structure with orientation along the AC electric field between the electrode gaps. Both experimental results and theoretical analysis have indicated that a large orientation torque and force can be achieved by choosing an optimal frequency and decreasing the conductivity of the medium to a low level, where the orientation torque weakly depends on the frequency. In this paper, electromechanical experiments were performed to demonstrate the structural and functional anisotropy of the electro-oriented structure.
URI: http://hdl.handle.net/10397/26120
ISBN: 0-7803-9475-5
ISSN: 1084-6999
DOI: 10.1109/MEMSYS.2006.1627723
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