Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/26018
Title: Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air
Authors: Zhang, XC
Wu, Y
Yu, F
Wu, FF
Wu, J
Chan, ASC
Keywords: Asymmetric catalysis
Copper
dipyridylphosphine ligands
Enantioselective hydrosilylation
Ketones
Issue Date: 2009
Publisher: Wiley-VCH
Source: Chemistry - a European journal, 2009, v. 15, no. 24, p. 5888-5891 How to cite?
Journal: Chemistry - a European journal 
Abstract: Copper (II)-dipyridylphosphine catalyst was used in the asymmetric hydrosilylation of simple ketones under ambient conditions in competitive levels of enantioinduction and activity. The experiment also described the utility of the combination of copper(II) salt/(S)-1/PhSiH3 in the enantioselective hydrosilylation of heteroaromatic ketones and several other ketonic substrates leading to some valuable pharmaceutical and agricultural chemical intermediates. A number of the resulting chiral alcohols represented valuable intermediates for some physiologically active compounds, with remarkable temperature effects on the asymmetric induction were observed in some cases of heteroaromatic ketones. The results show that the present catalyst system features widespread substrate scope, high air stability, fast rate of reaction, good-to-excellent enantioselectivity, and mild conditions thereby affording a practical protocol to a vast selection of optically enriched alcohols.
URI: http://hdl.handle.net/10397/26018
ISSN: 0947-6539
EISSN: 1521-3765
DOI: 10.1002/chem.200900499
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