Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25876
Title: Organocatalytic asymmetric aldol reaction of ketones with beta,gamma-unsaturated alpha-keto esters : an efficient access to chiral tertiary alcohol skeletons
Authors: Li, P
Chan, SH
Chan, ASC
Kwong, FY 
Keywords: Aldol reaction
Esters
Beta-hydroxy carbonyl compounds
Ketones
Organocatalysis
Issue Date: 2011
Publisher: Wiley-VCH
Source: Advanced synthesis & catalysis, 2011, v. 353, no. 7, p. 1179-1184 How to cite?
Journal: Advanced synthesis & catalysis 
Abstract: This update describes a highly efficient organocatalytic aldol reaction of ketones and beta,gamma-unsaturated alpha-keto esters for constructing the chiral tertiary alcohol motif. With the application of 9-amino(9-deoxy)epi-Cinchona alkaloid and an acidic additive as catalysts, both acyclic and cyclic ketones react with beta,gamma-unsaturated alpha-keto esters smoothly to afford aldol adducts in good to excellent yields and asymmetric induction. This protocol offers a new pathway for the construction of adjacent chiral carbon centers and the synthesis of chiral beta-hydroxy carbonyl compounds.
URI: http://hdl.handle.net/10397/25876
ISSN: 1615-4150
EISSN: 1615-4169
DOI: 10.1002/adsc.201000982
Appears in Collections:Journal/Magazine Article

Access
View full-text via PolyU eLinks SFX Query
Show full item record

SCOPUSTM   
Citations

29
Last Week
1
Last month
Citations as of Oct 17, 2017

WEB OF SCIENCETM
Citations

26
Last Week
0
Last month
0
Citations as of Oct 16, 2017

Page view(s)

55
Last Week
2
Last month
Checked on Oct 16, 2017

Google ScholarTM

Check

Altmetric



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.