Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25855
Title: The use of a noninvasive and nondestructive method, microcomputed tomography, to evaluate the anti-osteoporotic activity of erxian decoction, a Chinese medicinal formula, in a rat model of menopausal osteoporosis
Authors: Sze, SCW
Tong, Y
Lai, YM 
Zhang, YB
Yow, CMN
Ng, TB
Keywords: Bone
Cellular biophysics
Computerised tomography
Drugs
Nondestructive testing
Physiological models
Issue Date: 2009
Publisher: IEEE
Source: 2nd International Conference on Biomedical Engineering and Informatics, 2009 : BMEI '09, 17-19 October 2009, Tianjin, p. 1-3 How to cite?
Abstract: Aim of the study: The anti-osteoporotic activity of Erxian Decoction, a chinese medicinal formula, in a rat model of menopausal osteoporosis was evaluated by microcomputed tomography (microCT). Materials and methods: Menopause causes a decline in both endocrine function and bone mineral density in human. In this study, 20-month-old female Sprague-Dawley-rats (SD-rats) with a low serum estradiol level and bone mineral density were employed. The anti-osteoporotic activity of EXD was assessed by the determination of trabecular material bone mineral density at the L2 mid-vertebral body after treatment. Serum estrogen levels were also determined to assess the effect of EXD on the endocrine status. Results: Results revealed a significant elevation in serum estradiol level and trabecular bone mineral density at the L2 mid-vertebral body in the EXD-treated menopausal rat model. Conclusions: The results obtained from the present investigation revealed that the EXD had anti-osteoporotic activity as evidenced by an increase of serum estradiol level and bone mineral density.
URI: http://hdl.handle.net/10397/25855
ISBN: 978-1-4244-4132-7
978-1-4244-4134-1 (E-ISBN)
DOI: 10.1109/BMEI.2009.5304821
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