Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25792
Title: Investigation of the collagen fibril distribution in the medial collateral ligament in a rat knee model
Authors: Fung, DTC
Ng, GYF 
Leung, MCP
Tay, DKC
Keywords: Collagen fibril
Electron microscope
Ligament
Issue Date: 2003
Source: Connective tissue research, 2003, v. 44, no. 1, p. 2-11 How to cite?
Journal: Connective Tissue Research 
Abstract: This study compared the collagen fibril diameter distribution among six anatomical sites of the rat medial collateral ligament (MCL). Ultrathin MCL sections from 4 male Sparague-Dawley rats were examined electron microscopically. With an automated quantitation method, 41,638 fibrils were measured and compared among the periphery and core regions of the femoral, middle, and tibial portions of the MCL. Results demonstrated significant difference (p < .0033) in mean fibril diameter distribution among the six sites. The mass-averaged diameters of the core and peripheral fibrils were between 175.53 to 190.82 nm and 88.47 to 109.18 nm, respectively, with the peripheral fibrils more homogeneous in size. The fibrils occupied 36.7% to 57.1% of the cross-sectional area of the ligament. About 50% of the fibrils had an oblique factor of 0.8-1.0, implying that most fibrils were aligned longitudinally. This study has provided a detailed profile of the collagen fibril distributions in rat MCL.
URI: http://hdl.handle.net/10397/25792
ISSN: 0300-8207
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