Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25773
Title: Gleditsia sinensis fruit extract-induced apoptosis involves changes of reactive oxygen species level, mitochondrial membrane depolarization and caspase 3 activation
Authors: Chui, CH
Lau, FY
Chan, ASC
Cheng, GYM
Wong, RSM
Lai, KB
Kok, SHL
Yeung, TT
Teo, IT
Yau, MY
Cheung, F
Cheng, CH
Tang, JC 
Keywords: Reactive oxygen species
Mitochondria
Caspase 3
Issue Date: 2005
Publisher: Professor D A Spandidos
Source: International journal of molecular medicine, 2005, v. 15, no. 3, p. 539-543 How to cite?
Journal: International Journal of Molecular Medicine 
Abstract: Recently, we have shown that the anomalous fruit extract of Gleditsia sinensis (GSE) processes apoptotic activity on numerous solid turnout and leukaemia cell lines as well as primary cultured leukaemia cells obtained from bone marrow aspirate of patients. GSE treated cancer cells exhibited apoptotic features as readily illustrated by morphological investigation, DNA fragmentation analysis and TUNEL labelling methods. Elevation of intracellular superoxide dismutase activity was observed. However, the detailed mechanism still remains undefined. Here we further demonstrated that cell cycle arrest, increment of hydrogen peroxide production, changes of intracellular acid-base equilibrium and mitochondrial membrane potential depolarization (Delta psi(m)) were induced from cancer cells after GSE incubation. Caspase 3 protease activity was significantly enhanced upon GSE treatment. Taken together, a defined signaling pathway for the mechanistic action of GSE on cancer cells was worked out.
URI: http://hdl.handle.net/10397/25773
ISSN: 1107-3756
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