Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25771
Title: Catalyst-free aza-Michael addition of azole to beta,gamma-unsaturated-alpha-keto ester : an efficient access to C-N bond formation
Authors: Wang, J
Li, PF
Chan, SH
Chan, ASC
Kwong, FY 
Issue Date: 2012
Source: Tetrahedron letters, 2012, v. 53, no. 23, p. 2887-2889
Abstract: An efficient aza-Michael addition of azoles to beta,gamma-unsaturated-alpha-keto esters under room temperature conditions has been developed. In this conjugate addition, no additional catalyst is employed. Azole reacts with beta,gamma-unsaturated-alpha-keto ester smoothly to afford new C-N bond adducts in good to excellent yields (up to 96%).
Keywords: Michael addition
Azole
Nitroalkene
Nitroolefin
Amination
Publisher: Pergamon Press
Journal: Tetrahedron letters 
ISSN: 0040-4039
EISSN: 1873-3581
DOI: 10.1016/j.tetlet.2012.03.132
Appears in Collections:Journal/Magazine Article

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