Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25740
Title: A radical process towards the development of transition-metal-free aromatic carbon-carbon bond-forming reactions
Authors: Chan, TL
Wu, Y
Choy, PY
Kwong, FY 
Keywords: Biaryl
C-C bond formation
Cross-coupling
Homolytic aromatic substitution
Radical reactions
Issue Date: 2013
Publisher: Wiley-VCH
Source: Chemistry - a European journal, 2013, v. 19, no. 47, p. 15802-15814 How to cite?
Journal: Chemistry - a European journal 
Abstract: Transition-metal-free cross-coupling reactions have been a hot topic in recent years. With the aid of a radical initiator, a number of unactivated arene C-H bonds can be directly arylated/functionalized by using aryl halides through homolytic aromatic substitution. Commercially available or specially designed promoters (e.g. diamines, diols, and amino alcohols) have been used to make this synthetically attractive method viable. This protocol offers an inexpensive, yet efficient route to aromatic C-C bond formations since transition metal catalysts and impurities can be avoided by using this reaction system. In this article, we focus on the significance of the reaction conditions (e.g. bases and promoters), which allow this type of reaction to proceed smoothly. Substrate scope limitations and challenges, as well as mechanistic discussion are also included.
URI: http://hdl.handle.net/10397/25740
ISSN: 0947-6539
EISSN: 1521-3765
DOI: 10.1002/chem.201301583
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