Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/25726
Title: Electrical stimulation at the dorsal root ganglion preserves trabecular bone mass and microarchitecture of the tibia in hindlimb-unloaded rats
Authors: Lau, YC
Qian, X
Po, KT
Li, LM
Guo, X 
Keywords: Bone mineral density
CGRP
Disuse osteoporosis
Dorsal root ganglion
Electrical stimulation
Issue Date: 2014
Publisher: Springer-Verlag London Ltd
Source: Osteoporosis international, 2014, v. 26, no. 2, p. 481-488 How to cite?
Journal: Osteoporosis International 
Abstract: Summary: This study seeks to investigate the effect of electrical stimulation (ES) at dorsal root ganglion (DRG) on disuse bone loss in a rat model. Hindlimb unloading for 14?days resulted in significant bone loss in rat tibia while rats with ES at DRG showed a significant reduced bone loss.Introduction: Mechanical unloading induces osteoporosis in both human and animals. Previous studies demonstrated that electrical stimulation (ES) to dorsal root ganglion (DRG) could trigger secretion of calcitonin gene-related peptide (CGRP) which plays an important role in bone modeling and remodeling. This study seeks to investigate the effect of ES to DRG on disuse bone loss in a rat model.Methods: Twenty-four rats were randomly assigned in three experimental groups: cage control (CC), hindlimb unloading (HU), and hindlimb unloading with ES (HUES)
URI: http://hdl.handle.net/10397/25726
ISSN: 0937-941X
DOI: 10.1007/s00198-014-2866-3
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